Clinical Immunology and Rheumatology

The Unit of Clinical immunology and Rheumatology at San Raffaele Hospital features a team of highly trained physicians from different medical specialties (Immunology, Rheumatology, Allergy, Hematology, and Internal Medicine) working together to diagnose, treat and manage immune-mediated and rheumatic diseases.

Our physicians also work tightly with a network of dedicated consultants (including Cardiologists, Neurologists, Ophthalmologists, Chest and ENT physicians, Obstetricians and Gynecologists) to effectively manage and treat all the complex manifestations of immune-mediated diseases, which typically involve different organs and systems at the same time. Specific attention is also devoted to the care of patients with rare immune-mediated diseases. By this coordinated approach, we strive to assist our patients as whole-persons, as unique individuals to care for, and not as a sum of medical manifestations to be treated.

Main conditions treated

  • Arthritides: rheumatoid arthritis, psoriatic arthritis, reactive arthritis (Reiter’s), ankylosing spondylitis, acute rheumatic fever, gout and other crystal arthritides, osteoarthritis
  • Connective tissue diseases: systemic lupus erythematosus (SLE), Sjogren syndrome, systemic sclerosis (scleroderma), CREST syndrome, Raynaud’s phenomenon and syndrome, dermatomyositis, polymyositis, mixed connective tissue disease, undifferentiated connective tissue disease, overlap syndromes, anti-phospholipid syndrome
  • Vasculitides: giant-cell arteritis (temporal arteritis/Horton’s), polymyalgia rheumatica, Takayasu’s arteritis, panarteritis nodosa, granulomatosis with polyangiitis (Wegener’s disease), eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), microscopic polyangiitis, Henoch-Schonlein purpura, cryoglobulinemia, thromboangiitis obliterans (Buerger’s disease)
  • Other systemic rheumatologic diseases: sarcoidosis, Behçet’s disease, adult onset Still’s disease, autoinfammatory disorders of the adult, erythema nodosum, Erdheim-Chester disease, IgG4-related disease, relapsing polychondritis, Cogan’s syndrome, autoimmune hepatitis, primary biliary cirrhosis
  • Primary immunodeficiencies of the adult
  • Immune-mediated disorders in the pregnant woman
  • Allergic diseases: allergic rhinitis and rhinoconjunctivitis, allergic asthma, food/additive intolerance and allergy, contact and atopic dermatitis, hypersensitivity reactions to drugs, gluten hypersensitivity and allergy.


The Unit is equipped with many outpatient consultation room and a biologic drug infusion and distribution facility. Compromised patients may be admitted to the Unit of Medicine and Clinical Immunology as inpatient. We regularly perform video-capillaroscopy, synovial fluid sampling and intra-articular injections.


The research activity of the group focuses on the pathogenesis of systemic rheumatologic and immunologic diseases, of allergic diseases and of rare immune-mediated conditions. We are particularly interested in the identification of new disease biomarkers for diagnosing and categorizing such conditions and of new potential therapeutic targets. The Unit conducts several spontaneous and sponsored clinical trials.


Head of the Unit is Prof. Maria Grazia Sabbadini, MD Immunologists & Rheumatologists: Lorenzo Dagna, Angelo Manfredi, Luisa Praderio, Patrizia Rovere-Querini, Elena Baldissera, Matteo Bellone, Enrica Bozzolo, Chiara Salmaggi, Raffaella Scotti, Patrizia Aiello, Laura Ferrario, Stefano Franchini Hematologist: Moreno Tresoldi Allergologists: Giselda Colombo, Nicoletta Saporiti, Mona-Rita Yacoub, Samuele Burastero, Francesca Crosti, Angela Maltagliati, Giuditta Minutiello Hepatologists: Massimo Memoli, Magda Vecellio, Teresa D’Aliberti